The Roman Inquisition was reconstituted in 1542 to combat the menace of Protestantism in the Italian peninsula, whereas the Spanish Inquisition had been created more than half a century earlier to deal with massive numbers of converted Jews. […]
Wherever one turns, therefore, it appears that Italian Inquisitors were becoming preoccupied with superstitious magic and witchcraft well before 1600 – unlike their Spanish counterparts, who held barely 2 percent of their pre-1615 trials for such offenses. In the seventeenth century this Italian concern with magicians and witches persisted, while the attention that needed to be devoted to heretics continued to diminish. Illicit magic alone constituted over 40 percent of all cases both at Venice and in the Friuli and for close to 40 percent in Naples. Even in Sicily, where it accounted for only 25 percent Holy Office activity after 1615, illicit magic was the largest single category and the 310 trials for this offense were the largest total from any of the twenty Spanish tribunals during this period. After 1600, prosecution of magicians dominated the business of the Italian inquisitions, far more dramatically than it ever did in any part of the Spanish system: in the nine Castilian tribunals, for example, “superstition” accounted for only 12 percent of the 6,240 trials held between 1615-1700. As late as the decade 1701-1710, illicit magic accounted for 69 percent of all Venetian inquisitorial cases and 61 percent of those at Naples.
E. William Monter and John Tedeschi, “Toward a Statistical Profile of the Italian Inquisitions, Sixteenth to Eighteenth Centuries”. The Inquisition in Early Modern Europe: Studies on Sources and Methods (1986)